Background: Severe infection can become worse by the clinical illness known as sepsis. In critically ill patients, the neutrophil-lymphocyte count ratio [NLCR] assesses inflammation and stress in a straightforward, quick, and affordable manner. Objectives: To test determine neutrophil-lymphocyte count ratio's importance in sepsis diagnosis comparing to other indicators like WBC count, CRP, and neutrophil count. Patients and methods: In 100 patients participated in this prospective cohort study included. Of them, 50 were ICU patients who had sepsis and 50 were not. All patients had thorough history taking, thorough clinical examinations, and standard laboratory tests. confirmation of infection, radiological investigations and inflammatory markers. By dividing the ratio of neutrophils to lymphocytes, or the lymphocyte count divided by the neutrophil count was determined. Results: There were statistically significant variations in SOFA and CRP across the examined groups. In terms of NLCR, Between the groups that were assessed, there were statistically significant differences, with greater mean values seen in the group with sepsis. There was statistically significant data as well relation regarding mortality with significant higher deaths in sepsis group than no sepsis. We showed the validity of NCLR at cutoff value of > 6.65, as sensitivity was 64% and specificity was 60%. But at a cutoff value of > 10.7 to predict mortality, sensitivity was 68.2% and specificity was 67.9%. positive correlations between were statistically significant between CRP and temperature and between NLCR and SOFA. Conclusion: However, the delicateness and precision of the association between higher NLCR and greater mortality in adult septic patients were constrained.