Background: Corona Virus disease 2019 (COVID-19) epidemiology and quarantine have an influence on female sexual health and function. Sexual intercourse frequency decreases. The pandemic is connected with a decline in sexual life quality, sexual desire and intercourse frequency decrease during closure. In addition, the pandemic has an effect on the decline in desire for conception, the decline in female contraception, and the rise in menstruation diseases. In addition, the COVID19 pandemic leads to an enormous rise in stress and anxiety levels, as well as a considerable reduction in interpersonal contact. Typically, major disasters result in widespread sexual dysfunction and diminished sexual life pleasure. This may indicate that when an issue affects everyone similarly and may have future ramifications, its influence on sexual elements is relatively unfavorable. The Female Sexual Function Index (FSFI) is one of the most widely utilized scales for assessing sex life and is regarded the "gold standard." It evaluates several facets of sexuality. Performing the questionnaire twice provides the opportunity to examine the influence of certain circumstances on sexual life. Due to medical advancements, it is vital to identify sexual dysfunctions in women, who, if left untreated, are connected with a greater risk of melancholy, anxiety, and worse life quality. This article aimed to explain COVID-19 Pandemic impact on Egyptian female sexual life.