Background and aim of the work: Patients with androgenetic alopecia (AGA) was correlated with higher prevalence of insulin resistance, hypertension, coronary artery disease, obesity, atherosclerosis and aberrant serum lipid profile. Endocan is a possible immunoinflammatory indicator associated with cardiovascular disease. Patients with AGA appear to be at an increased risk of developing CAD, therefore, clinical evaluation of cases with AGA of grade II is recommended The carotid intima-media thickness (CIMT) is a powerful indicator of future cerebrovascular and cardiovascular disorders. This research intended to examine serum level of endocan and CIMT in male AGA patients. Patients and Methods: that research conducted in Dermatology Department, Benha University Hospital, on sixty AGA participants with 20Y old age and gender-matched individuals during the period from January 2021 to August 2021. Results: endocan level was considerably lower in control compared to AGA group, but no critical change was seen among groups concerning CIMT. Conclusion: Serum endocan was considerably lower in control compared to AGA group, but concerning CIMT, a non-critical change was seen among groups.