Background: Breast cancer is both the most commonly identified life-threatening cancer in women and the top cause of cancer mortality in women worldwide. The best line of protection against breast cancer is still an early diagnosis. Examples of screening methods are as follows: Self-examination, the clinical inspection, and mammography altogether with Ultra-sonography. Aim of the work: The aim of the work is to evaluate the role of breast elasto-graphy combined with mammography as a diagnostic method in indeterminate breast lesions. Patient and methods: This prospective cohort study was conducted upon 50 female patients with breast mass/masses at Radiology Department of Tanta Cancer Center referred from Surgery Department & early detection unit. The present study demonstrated in correlation with other studies that breast ultrasound elastrography is sensitive in diagnosis of indeterminate breast lesions however not reliable without other modalities. Results: The overall sensitivity of breast elasto-graphy in diagnosis of indeterminate breast lesions was about 66%.Conclusion:Elastography substantially improves the US capability in differentiating benign from malignant breast lesions, thus reducing the number of breast biopsies in benign nodule. Elastography is a useful complementary tool for undetermined breast lesions but cannot avoid fine needle aspiration or core biopsy if ultrasound features are clearly suspicious.