Background: UA levels and serum bilirubinhave a role in pathogenesis of acne.Data Sources: Using Medline resources [Pub Med and Medscape] and information about the significance of serum bilirubin and UA levels in acne that is up to date through 2023.Study Selection:For inclusion, each study underwent an independent evaluation. They were involved if they matched the following requirements: 1. Published in English language. 2. Published in peer-reviewed journals.3. Discuss serum bilirubin and UA levels role in pathogenesis of acne.Data Extraction:Studies were disqualified if they didn't meet the criteria for inclusion. Evaluation of the quality of the study involved determining whether it had received ethical approval, eligibility criteria that were clear, proper controls, adequate information, and established assessment strategies. Employing a data collection form, data from each eligible study were independently abstracted to gather details on the study results we were interested in. Conclusions: We can safely conclude that bilirubin and UA may have a possible function in acne vulgaris [AV] pathogenesis.