Background: Osteoarthritis (OA) is among the world's leading disability causes. According to epidemiological research, there are approximately 43 million afflicted individuals in the U.S alone and approximately 15 percent of the global community. That research purposed to perform a systematic literature reviewregarding high tibial osteotomy (HTO) as an effective way for management of medial compartmental OA knee and criteria of patient selection for good surgical results of HTO. Methods: This systematic review was conducted utilizing SCOPUS, PubMed, Cochrane Library and Web of Science electronic databases. Authors performed and revised search techniques to increase their sensitivity. Search method comprised various phrases and synonyms for osteoarthritis and knee joint in conjunction with high tibial osteotomy, indications, arthroplasty, and life quality, functional capacity, or physical exercise. Results: Twelve papers enrolled in this study from 2013- 2018 with 6943 patients underwent high tibial osteotomies, 83% of the studies were retrospective and 17% were prospective.There were 1687 male patients and 1408 female patients among the 3958 patients admitted in 7 articles that described the allocation of gender in their investigations. The percentage of male to female patients was 42.6% to 35.5%, correspondingly. In these investigations, patientsaverage age who received high tibial osteotomies was 49.4 years. The follow up duration of patients was estimated as 3.6 years. Conclusions: Literature demonstrates that instability is not a true contraindication for HTO, regardless of whether or not the operation is graded, provided it is well managed. When this recommendation was followed and the procedure's limitations were considered, HTO had favourable results, with a mean 5-year and 10-year survival rate of 89.3 percent (range: 75-98.7 percent) and 77.6 percent (range: 51-97.7 percent), correspondingly.