Background: Acne scars may significantly affect a person's self-esteem and quality of life. Fractional CO2 laser therapy has emerged as a possible treatment for acne scars. Objectives: This article aims to offer a complete overview of fractional CO2 laser therapy for the treatment of acne scars. It discusses the classification of acne scars, the principles and types of fractional CO2 laser , its efficacy and safety, the procedure and post-treatment care, combination therapies and adjunctive treatments, as well as future directions and emerging technologies in the field. Conclusions: Fractional CO2 laser is a promising method for the treatment of acne scars, with consistent effectiveness and a reasonably safe profile when administered by trained specialists. It provides benefits such as scar resurfacing, minimum recovery time, and personalised treatment alternatives. However, it is essential to consider individual scar features, skin type, and patient preferences while picking the most appropriate treatment methodBackground: Acne scars may may significantly affect a person's self-esteem and quality of life. Fractional CO2 laser therapy has emerged as a possible treatment for acne scars. Objectives: This article aims to offer a complete overview of fractional CO2 laser therapy for the treatment of acne scars. It discusses the classification of acne scars, the principles and types of fractional CO2 laser , its efficacy and safety, the procedure and post-treatment care, combination therapies and adjunctive treatments, as well as future directions and emerging technologies in the field. Conclusions: Fractional CO2 laser is a promising method for the treatment of acne scars, with consistent effectiveness and a reasonably safe profile when administered by trained specialists. It provides benefits such as scar resurfacing, minimum recovery time, and personalised treatment alternatives. However, it is essential to consider individual scar features, skin type, and patient preferences while picking the most appropriate treatment method.