SARS-CoV-2 infection can lead to the development of ARDS, which is associated with high mortality rates. COVID-19 has also been linked to myocardial injury and alterations in RV strain, which have been identified as independent predictors of poor prognosis. This study investigated the prevalence and prognostic significance of right heart failure and right ventricular-arterial uncoupling in patients with COVID-19 complicated by ARDS. The research comprised a total of ninety-four individuals with acute respiratory failure caused by COVID-19. Using complete transthoracic echocardiography, the link between right ventricular function and pulmonary circulation was investigated, with an emphasis on the ratio of TAPSE to PASP. TAPSE was substantially higher in the group of survivors, but PASP was significantly higher in the group of the dead. LVEF, LVESD, frequency of tricuspid regurgitation, and LAD also differed considerably between the surviving and dying groups. There was no statistically significant difference between the two groups in terms of LVEDD. In conclusion, COVID-19-induced ARDS is linked with a considerable and early separation of right ventricular function from pulmonary circulation. Evaluation of this uncoupling by noninvasive echocardiography using the TAPSE/PASP ratio has been shown to be a significant predictor of patient outcome.