Background: Breast calcifications may be the sole observable indicator of early breast cancer, making them a significant finding on a mammography. This research aimed to evaluate the usefulness of ultrasonography and ultrasound-guided interventional treatments in the assessment of breast calcification diagnosed by mammography. Methods: This investigation was done on thirty individuals whose mammograms revealed worrisome microcalcifications. Each patient had a comprehensive history, physical examination, laboratory analysis, mammography, ultrasound, core biopsy under sonographic guidance, and guide wire localisation under sonographic direction. Twenty patients got ultrasound-guided breast biopsies, and ten patients had ultrasound-guided wire localisation. Results: 75 percent of the 20 lesions that underwent guided biopsy were diagnosed sonographically as masses, while the other lesions were classified as parenchymal distortions or calcifications. 75% of the cases were malignant, whereas 25% were benign lesions. In 7/10 (70%) instances, wire localization was successful; in 2 cases, the wire reached the posterior side of the lesion but did not transfix it, and in 1 case, the wire reached only the anterior aspect of the lesion. Conclusions: Based on the findings of the current investigation, we have shown that targeted US is an excellent tool for the characterisation of microcalcification observed on mammography and may be useful for predicting invasive breast tumours. Sonographically detectable microcalcifications appear as small echogenic, non-shading foci, particularly if they are coupled with sonographic hypoechoic lesions.