The purpose of this study is to examine the correlation between IL-15 levels in the blood of vitiligo patients and those of healthy controls. Although interleukin-15 (IL-15) has been demonstrated to have an important role in the pathophysiology of numerous autoimmune illnesses, its impact in vitiligo patients has not been well studied. Medline databases (Pub Med and Medscape) were searched for and reviewed for information on IL-15's involvement in vitiligo patients up till 2022. The papers that were included in the meta-analysis were chosen based on a strict set of criteria. The following requirements were met for inclusion: To begin with, it is written in English. 2. Appear in publications with strict peer review. Provide an update on the function of IL-15 in vitiligo patients who will have access to this therapy between now and 2023. Information Extraction: Studies were not included if they did not meet the inclusion criteria. Ethical permission, eligibility criteria, controls, information, and established assessment measures were all considered as part of a comprehensive evaluation of the study's quality. All of the studies that met the criteria were analyzed, and data were abstracted using a standardized method to identify any relevant information about the studies' results that we were interested in. This research leads us to the conclusion that IL-15 is likely involved in the immunological etiology of vitiligo.Interleukin-15 and vitiligo are both important terms.