In order to properly diagnose kidney stones and determine which therapeutic approach should be used for treatment, imaging is an essential initial step. Radiography, ultrasound, computed tomography, and magnetic resonance imaging are all viable options for these individuals. Evaluation of nephrolithiasis patients is best done using CT of the abdomen and pelvis because of its high degree of accuracy. The purpose of this research is to better comprehend the pathophysiology of stone formation by comparing the renal papillary density of stone formers of all prevalent stone subtypes to that of non-stone formers. Renal papillary density was compared between calyces in the kidney with a stone, calyces in the kidney without a stone, and calyces in the control group. Moreover, the density of the papillary structures in the kidneys was compared between kidneys where the stones were located. Methods: Fifty people participated in the trial, 25 of whom had unilateral renal stones and 25 of whom were healthy controls. Study participants were seen in the outpatient clinics of both Sheikh Zayed and the International Hospital for Urology and Nephrology. Results: The major findings of the research showed that the mean density of the upper, middle, and lower calyces of the renal papillae varied significantly across the study groups, with the greatest mean density found in the stone-bearing kidneys and the lowest density found in the normal group. This study's findings that individuals with renal stones had a higher papillary density compared to normal participants have implications for the diagnosis and follow-up of these patients. Renal stones of all types are radiographically characterised by increased renal papillary Hounsfield density. The involvement of papillary plaques and concretions in stone formation is supported by these radiography findings.