Background: One of the most pressing health issues of our day is the epidemic of obesity and excess weight. When compared to more conventional methods of treating obesity, bariatric surgery has been shown to be the most successful option. The primary objective of this research was to examine the similarities and differences between SG and SASI bypass in terms of weight reduction length, maintenance, failure, cost, time of surgery, learning curve and postoperative complications, and improvement in comorbidities after 12 months of follow-up. Methods: The General Surgery Department at Benha University Hospital was the site of this randomised, prospective clinical trial. Forty patients with morbid obesity who don't regularly consume sweets will be split evenly between two groups, with group I receiving laparoscopic SG and group II receiving laparoscopic SASI. Duration of the trial varied between 6 and 12 months. The present investigation found no statistically significant difference between the two groups in terms of surgical duration or length of hospital stay. When comparing the two groups, there was no discernible change in the preoperative laboratory values analysed. There was a significant difference in ALT levels between the two groups at six months postoperative compared to preoperative levels. Comparing the two groups 12 months after surgery, there was a substantial difference in TLC and HDL levels. Time intervals between preoperative and postoperative measurements of TC, TG, LDL, and FBS were significantly shorter in group 1 (laparoscopic SG) compared to group 2. We found that AST, TC, TG, LDL, and FBS levels in Group 2 (SASI) decreased significantly between pre- and post-operative follow-up periods. While there was a statistically significant rise in HDL between pre- and post-operative follow-up, there was a statistically significant drop in BMI between pre- and post-operative follow-up for both groups. Concerning complications, there was no discernible difference between the two groups. Overall, the SASI bypass has very favourable outcomes, is less invasive than the Santoro's procedure and BPD alterations, and is founded on the physiological principles of digestive adaptation.