Hair loss disorders are divided into 2 major groups: Cicatricial and non-Cicatricial Alopecies. Cicatricial alopecies are disorders in which the hair follicle is replaced by fibrous scar tissue leading to permanent hair loss. In Non-cicatricial alopecies hair follicles are preserved and hair growth can resume when the cause of the problem is eliminated [1].Dickkopf-1 encodes a potent and specific endogenously-secreted Wnt antagonist that binds and inhibits LRP (Lipoprotein Receptor-Related Protein)5/6 receptors that are involved in canonical Wnt signaling during hair induction and growt[2]  Aim: To evaluate the serum levels of DKK-1 in patients with cicatricial alopecia and non-cicatricial alopecia to determine its role in the pathogenesis of both disorders.Patients and methods: This prospective case-control study included sixty patients with cicatricial alopecia, sixty patients with non-cicatricial alopecia and twenty persons of apparently healthy subjects as a control group of the same age and sex. Patients were selected from the Dermatology outpatient clinic of Benha University Hospitals and Benha Teaching Hospital in the period between December 2019 and June 2020.Results: There was an overall significant difference in serum DKK-1 between the studied groups .Post-hoc analysis revealed significantly higher DDK-1 in the non-cicatricial group (median = 14.6, range = 11.4 – 57) than in the cicatricial group (median = 9.85, range = 3.4 – 67.3) and the control group (median = 4.93, range = 1.86 – 40.6).Conclusion: DKK-1 has important role for the pathogenesis of alopecia through documenting higher serum DKK-1 levels in patients with hair loss disorders compared to controls .Serum DKK-1 was a non-significant predictor of cicatricial alopecia, while it was a significant predictor for non-cicatricial alopecia.