Anaphylaxis, a potentially fatal hypersensitivity response that affects the whole body, has a long and complicated history. Complications with the airway (pharyngeal or laryngeal edoema), breathing (bronchoconstriction with tachypnea), and circulation (low blood pressure and/or tachycardia) may develop rapidly, posing a serious danger to the patient's life. Abnormalities of the skin and mucosa are common in patients with this illness. The purpose of this research was to examine emerging tendencies and developments in perioperative anaphylaxis. To sum up, antibiotics and NMBAs are the most common causes of perioperative anaphylaxis, which is generally IgE-mediated. When the start is sudden, it might be difficult to make a diagnosis due to the variability in clinical characteristics. The clinical appearance dictates the course of treatment. Adrenaline and intravenous fluids are the bedrock of care fluids. Retrospectively determining the reaction's genesis by tryptase concentrations and skin tests is important; findings must be connected with the clinical history. In order to guarantee future anaesthetics are risk-free for patients, it is necessary to do a thorough evaluation that identifies the offending medicine and suggests safe alternatives.