Background: Several in vitro antimicobial activity experiments were performed on apple (Malus domastica), banana (Musa parasidica), and wild plants (Zimia spinosa, Saeuda aegyptica, Chenopodium mural, and Caltropis procera). Chemical investigation has shown that each of these plant extracts has a unique combination of active compounds. Methanolic extracts inhibited (staphylococcus. aureus) and (escherichia.coli) growth in preliminary testing of their antibacterial action, whereas salmonella. enterica proved resistant to most extracts. Apple and banana skins, as well as the aerial portions of the plants Zizea spinosa, Saueda aegyptiaca, Chenopodium mural, and Caltrpis procera, were removed to test for the presence of potentially active crude compounds (dis.water,acetone, and methanol). The mic (minimum inhibitory concentration) values of banana and chenopodium methanolic extracts were found to be 1.562 mg/ml and 3.124 mg/ml for Escherichia coli and 6.25 mg/ml and 1.25 mg/ml for Staphylococcus aureus, respectively. Experiments were then conducted to confirm that bananas and chenopodium contain highly active compounds (tests for antioxidant activity, biofilm development and reduction, and antihemolytic action). Banana methanolic extract had a significant inhibitory effect on staph.aureus and e.coli, as shown by a transmission electron microscopy (tem) experiment.