Aim: This report aims to contribute to the current knowledge base by presenting a unique case of intra-oral Spindle cell lipoma (SCL) arising in an uncommon location, the buccal mucosa, and affecting a less frequent sex, female. SCL poses a significant diagnostic challenge due to its histological resemblance to malignant neoplasms. This is compounded by the scarcity of comprehensive clinical data. Consequently, we provide a concise literature review on SCL to contribute to a comprehensive understanding of its clinical features, optimal treatment approaches, and long-term outcomes. Materials and methods: We present a clinical case of a female patient with a buccal mass. The excised soft tissue underwent histochemical and immunohistochemical staining (CD34) for confirmatory diagnosis. A comprehensive review of relevant literature on SCL was conducted, focusing on diagnostic criteria, differential diagnoses, treatment modalities, and reported patient outcomes. Results: Here, we report a case of SCL arising in the buccal mucosa of a female patient. Histopathological examination with both histochemical and immunohistochemical staining (CD34) confirmed the diagnosis. Our review of the literature emphasizes the rarity of SCL, the diagnostic challenges it presents, and the limited understanding of its typical clinical course and prognosis. Conclusion: This report contributes to the existing knowledge on SCL by presenting a unique case with an unusual location and affecting a less commonly reported patient sex.  Further research is necessary to establish a more comprehensive understanding of SCL's clinical behavior, optimal treatment approaches, and long-term outcomes to improve patient management.