Aim: This study aimed to compare the qualitative and radiographic outcomes of polyether-ether-ketone (PEEK) bars versus titanium bars fabricated using computer-aided design/computer-aided manufacturing (CAD/CAM) technique for use in mandibular hybrid prostheses. Materials and Methods: A total of 14 patients with completely edentulous mandibular arches opposing natural dentition were selected and divided into two groups; seven patients in each. All patients received implant-supported hybrid prostheses with a bar fabricated utilizing CAD/CAM milling technique on four dental implants. The bar was fabricated from titanium in Group I (control), while it was fabricated from PEEK in Group II. Furthermore, the study compared the two groups as follows: 1) Qualitatively, a questionnaire was used to evaluate patient satisfaction. 2) Radiographically, digital periapical imaging was used to measure marginal bone loss around implants. Finally, the results were statistically analyzed. Results: The patients in both study groups demonstrated increased levels of satisfaction, with no significant difference between them, except in terms of aesthetics, as the PEEK group exhibited superior aesthetic outcomes. In terms of marginal bone loss, a reduced marginal bone loss in the PEEK group was observed between the two groups during the 6- and 12-month assessments. Conclusion: PEEK material has proven to be a valuable alternative for bar fabrication in implant-supported hybrid prostheses for patients with a single edentulous mandible as the patients with PEEK bars demonstrated higher satisfaction and less marginal bone loss than those with titanium bars