Aim: to compare the retention, dentist and patient satisfaction of maxillary 3D-printed dentures fabricated from thermoplastic tray impressions to those made using conventional final impressions. Materials and Methods: Eleven completely edentulous patients were recruited for this double-blind, randomized, crossover clinical trial. Participants were randomly assigned to receive dentures fabricated from either conventional tray final impression or thermoplastic tray final impression for 14 days before switching to the other pair. Outcomes assessed were maxillary denture retention patient and dentist satisfaction with dentures. The outcomes were measured at baseline, and 14 days after denture insertion. After crossover, a similar protocol was implemented. For statistical analysis, a paired sample t-test with α=0.05 was used. Results: The trial was successfully completed by all participants. No significant difference in peak retention values was measured between the two groups at baseline (p = 0.27) and 14 days after denture insertion (p = 0.55). However, after 14 days of denture insertion, there was a statistically significant increase in retention values for both the conventional tray impression (p = 0.016) and the thermoplastic impression (p = 0.022). Regarding patients' satisfaction, there was a statistically significant difference in overall patient satisfaction favoring dentures fabricated from the thermoplastic tray, recording 3.40 ±1.23 (p = 0.021). There was no significant difference in overall dentist satisfaction with the denture in both groups. (p = 0.77) Conclusion: A simplified approach for maxillary denture fabrication using thermoplastic trays could have comparable outcomes with dentures made from conventional trays.