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Effectiveness of Zinc Supplementation in management of patients with symptomatic Benign Migratory Glossitis: A randomized control clinical and biochemical Study

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Oral Medicine, Periodontology and Oral Radiology Section

Abstract

Aim: To assess the effect of zinc supplements in management of symptomatic benign migratory ‎glossitis patients as a primary outcome and to evaluate levels of salivary zinc before and after ‎treatment as a secondary outcome.‎ Materials and Methods: A randomized controlled clinical and biochemical study was carried out on ‎‎48 patients diagnosed with geographic tongue. Patients were divided equally into two groups; the study ‎group received zinc supplements along with a zinc-rich diet for one month, while the control group ‎was given only a zinc-rich diet for the same duration. Clinical parameters including the size of red ‎atrophic areas (atrophic area length, atrophic area width), and visual analogue scale pain score. Both ‎parameters were recorded at baseline, after one month of treatment and after one month later without ‎treatment. Salivary samples were collected from both groups for biochemical analysis (measuring zinc ‎levels) at baseline and one month after treatment.‎ Results: Reduction in values of atrophic area length (9.88±5.51), atrophic area width (6.5±4.26) in ‎study group compared to (10.88±2.31), (7.38±2.14) respectively in control group, significantly higher ‎median values of   visual analogue scale pain score in control group (5.5), in comparison to study ‎group (3.5), (p=0.004), as well after one month of treatment, the study group exhibited a significantly ‎higher salivary zinc mean value compared to the control group (p=0.045).‎ Conclusion: Low dose of zinc sulphate has a significant therapeutic effect on the relief of subjective ‎symptoms in patients with BMG.‎

DOI

10.21608/asdj.2024.304744.1378

Keywords

Keywords: symptomatic, geographic tongue, Benign migratory glossitis, Zinc Sulphate

Authors

First Name

Mariam

Last Name

Eid

MiddleName

Mohamed

Affiliation

Master of Oral Medicine and Diagnosis Faculty of Dentistry, Ain Shams University, Cairo, Egypt

Email

drmariamhamouda@gmail.com

City

-

Orcid

-

First Name

Radwa

Last Name

Hussein

MiddleName

Ragheb

Affiliation

Associate Professor of Oral medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Cairo, Egypt

Email

radwa.ragheb@dent.asu.edu.eg

City

cairo

Orcid

0000-0002-2915-8827

First Name

Olfat

Last Name

Shaker

MiddleName

Gamil

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

olfat.shaker@kasralainy.edu.eg

City

-

Orcid

0000-0002-3031-3599

First Name

Suzan

Last Name

Ibrahim

MiddleName

Seifallah

Affiliation

Professor of Oral Medicine, Periodontology and Diagnosis, Faculty of Dentistry, Ain Shams University, Cairo, Egypt and Dean of Faculty of Oral and Dental Medicine, Nahda University in Beni Suef, Egypt.

Email

suzan.seifallah@dent.asu.edu.eg

City

cairo

Orcid

0000-0002-2335-6507

Volume

35

Article Issue

3

Related Issue

50595

Issue Date

2024-09-01

Receive Date

2024-07-18

Publish Date

2024-09-01

Page Start

244

Page End

255

Print ISSN

1110-7642

Online ISSN

2735-5039

Link

https://asdj.journals.ekb.eg/article_383036.html

Detail API

https://asdj.journals.ekb.eg/service?article_code=383036

Order

383,036

Type

Consort randomized clinical trials (RCT)

Type Code

1,639

Publication Type

Journal

Publication Title

Ain Shams Dental Journal

Publication Link

https://asdj.journals.ekb.eg/

MainTitle

Effectiveness of Zinc Supplementation in management of patients with symptomatic Benign Migratory Glossitis: A randomized control clinical and biochemical Study

Details

Type

Article

Created At

28 Dec 2024