O Aim:  To compare the impacts of deproteinization with sodium hypochlorite versus chlorine dioxide on the shear bond strength & resin dentin interface of composite filling material to dentin in primary teeth. Materials and methods: This investigation is an in-vitro investigation which included forty-eight human primary molars, extracted due to normal physiological resorption. Flat dentin surface was obtained (n=27) for evaluating shear bond strength, and 2 mm dentin slices (n=21) for evaluating resin dentin interface. Each deproteinizing agent has been applied to the dentin, followed by the usage of a universal adhesive in the self-etch mode. The control group didn't receive the deproteinizing agent. The shear bond strength of all samples has been assessed utilizing a universal testing machine. The failure mode has been measured by a stereomicroscope. The resin-dentin interface has been analyzed utilizing scanning electron microscopy. Results: The highest bond strength has been found in chloride dioxide group, followed by the control group, while the lowest bond strength has been found in sodium hypochlorite group. Concerning mode of failure, sodium hypochlorite group having a significantly greater percentage of adhesive failures than other groups. Regarding resin tags length, the greatest resin tags length values were found in chloride dioxide, followed by the control group, while the lowest values was found in sodium hypochlorite. Conclusion: Chlorine dioxide had the highest bond strength value while sodium hypochlorite showed lower value than control group. The highest adhesive failure was reported by the sodium hypochlorite while the higher mixed failure was reported for chlorine dioxide.