Aim: This study aimed to evaluate and compare the occlusal force distribution, measured with the T-Scan system, and electromyographic activity, assessed during static and dynamic tests with the Myowise device, between conventional and CAD/CAM neutral zone (NZ) complete dentures. Materials and Methods: This within-subject randomized controlled clinical trial involved eight completely edentulous patients, each receiving two types of NZ complete dentures: Conventionally (Group I) and CAD/CAM (Group II). The patients were randomly assigned to use one of the dentures first before switching to the other. At the time of denture insertion, occlusal force distribution was assessed using a T-scan. After two months, electromyographic activity was measured with a Myowise device. The independent t-test was used for intergroup comparisons. Results: Group II showed higher occlusal force distribution and greater mean muscle activity of the temporalis (TA) and masseter (MM) muscles during the static test (clenching) compared to Group I; however, these differences were not statistically significant. Group II also exhibited less asymmetry in TA and MM muscle activity between the right and left sides during the static test, without statistical significance difference. During the dynamic test (chewing), no significant differences in muscle activity were observed between the two groups on the "working side" and "balancing side" (p > 0.05). Conclusion: The NZ technique ensures balanced occlusal forces and optimal muscle coordination in complete dentures, whether created with CAD/CAM or conventional methods. Both approaches are equally successful in producing stable and functional dentures.