This study evaluated the impact of various remineralizing agents on microleakage around restored (with composite resin and glass ionomer restorations) demineralized enamel. Two restorative materials were used in this research and five remineralizing agents. Seventy bovine teeth were randomly divided into two groups, 35 of which were restored using resin composite restorations, and the other 35 were restored using glass ionomer restorations. Five teeth in each main group were left untreated and another five teeth in each group were demineralized only without any further treatment. Exposed enamel windows were subjected to five different remineralizing agents; 1: artificial saliva, 2: CCP-ACPF paste, 3: CCP-ACPF varnish, 4: self-assembling peptide; Curodont protect and 5: self-assembling peptide; Curodont repair. All treated groups were then subjected to pH cycling for 30 days. Microleakage test was done using dye penetration method followed by sectioning of the teeth and detection of the leakage score using stereomicroscope. The results of this study showed significantly increased leakage around glass ionomer restored samples compared to resin composite restored ones. Demineralized samples have shown the highest score of microleakage while CCP-ACPF varnish have shown the least microleakage score.