Brucellosis is the generic name for animal and human infections owing to different species of the genus Brucella mainly B. abortus and B. melitensis. B. melitensis was the prevalent serotype among sheep in Delta region, like bovine brucellosis. This paper tailors the epidemiology of brucellosis in small ruminants in Delta region pointing to the evaluation of the ordinarily used diagnostic bacteriological, molecular, and serological procedures. Herein, a broad review to shed light on the complexity of brucellosis plus discussing that the test and slaughter strategy should be applicable to free the herd out of quarantine, withal application of biosecurity practices and fair compensation policy for owners for good protection.