The study's goal is to show how selenium and Nano-selenium can reduce the negative side effects of cypermethrin in male rabbits. Forty rabbits were divided into four groups: normal control (G1), groups (G2, G3, and G4) that were given cypermethrin (1/100 of LD50, equivalent to 24 mg/kg b. wt) three times per week via stomach tube.G3 and G4 received oral treatments with selenium and Nano-selenium at doses of 0.5 mg/kg b.w.t. after two hours of cypermethrin for four weeks.
The administration of selenium and Nano-selenium (G3&G4) significantly reduced liver function enzymes and significantly increased growth, total protein (TP), albumin, and globulin levels compared to G2 levels, in addition to normalizing the lipid profile. Prominent downregulation of NO and pro-inflammatory cytokines (IL-6 and TNF-) levels and upregulation of lysozyme were elicited in Nano-selenium (G4) treatment than selenium (G3). Selenium and Nano-selenium (G3 and G4) increase testosterone and estrogen levels and decrease LH and FSH compared to G2. Nano-selenium administration (G4) could restore hormone levels to normal (G1).As opposed to Nano- selenium, administration of selenium (G3) showed a lower level of cypermethrin residue in the liver, kidney, and muscle. According to those findings, Nano-selenium outperformed selenium in its capacity to reduce cypermethrin adverse effects.