The current research assessed spirulina possible benefits effects in alleviating hormonal alterations and residue of liver and kidney fipronil and its metabolite in rabbits treated with dermal administration of 1/20 of LD50 (354 mg/kg fipronil) three times /week for four weeks. Sixty male New Zealand rabbits were distributed to four equal groups, control, spirulina (10 g/kg of diet daily), fipronil (1/20 of acute dermal LD50) and fipronil plus spirulina groups.
The data showed that fipronil caused hormonal changes and increased residue in the liver and kidney by extending the duration. Fipronil plus spirulina rabbit group showed a significant increase in serum levels of testosterone and luteinizing hormone (LH), as well as  triiodothyronine (T3) and thyroxine (T4) but significantly decreased serum levels of thyroid stimulating hormone (TSH) in contrast to the fipronil group. Spirulina showed non-significant effect on fipronil and fipronil sulfone residue of liver and kidney.