The current study was aimed to investigate the therapeutic effects of calcium disodium edetate (CaNa2EDTA) and Alpha lipoic acid (ALA) combined and moringa seeds powder (MOS.P) against lead and cadmium-induced neurotoxicity in rats. Twenty-four Albino male rats, weighing 158 ± 3 g were randomly divided into four groups (6 each). The first group served as a negative control group (-ve), second group served as untreated neurotoxicity group (+ve) and two treated groups with CaNa2EDTA and ALA combined and MOS.P. The experiment lasted for 60 days. Food intake and rat's weight were recorded to obtain nutritional parameters. Blood samples were collected to assays the levels of Cyclooxygenase-2 (COX-2), C- reactive protein (CRP), Lactic Dehydrogenase (LDH), Acetyl cholinesterase (AChE), Dopamine (DA), Serotonin (ST), lipid peroxidation, antioxidant enzymes activity, some kidney and liver functions. Also, the histopathological examination changes in brain tissue. The study results treated with CaNa2EDTA and ALA combined and MOS.P showed a significant improvement in serum levels of COX-2, CRP, LDH, AChE, DA, ST, Lipid peroxidation, Antioxidant enzymes activity, and some kidney and liver functions, when compared to untreated neurotoxicity group (+ve).
We recommend consuming moringa seeds and Alpha-lipoic acid with diets because they have anti-neurotoxicity and antioxidant properties, which play a significantly safer role than calcium disodium edetate in the treatment of lead-cadmium toxicity and inhibit its complications.