Background: Clinical teaching is a dynamic process; it's a form of interpersonal communication between a supervisor and students. challenges faced by nursing students in the clinical training areas need to be addressed to  improve effectiveness of clinical learning which effect on nursing students satisfaction. Nursing student satisfaction is a significant outcome of clinical training setting efficiency and influences student learning outcomes in clinical placements. The study aim: Was to assess the challenges in hospital clinical training areas and its relation to nursing students' satisfaction. Design: Descriptive correlational design was utilized. Setting: The current study was conducted at Faculty of Nursing, Benha University. The subjects: (538) nursing students from second and fourth academic years. Tools for data collection: Two tools used for data collection Hospital; Clinical Area Challenges, Nursing Students Satisfaction Questionnaire. Results: The highest challenges in hospital clinical training was supervisors' clinical training challenges, the lowest challenges was clinical training environment. Additionally, more than half of nursing students (57.2%) reported that they were high satisfied. Conclusion: There was highly statistically significant positive correlation between total challenges in clinical training areas and total nursing students satisfaction. Recommendation: Staff development programs for clinical instructors are needed to promote their skills in providing effective clinical training for nursing students. And supervisor needs to inform students about the philosophy and rules of the clinical training areas.