Background: Cervical cancer is a significant global health issue, particularly among women, with a considerable impact on morbidity and mortality rates. Aim: Was to study effect of chemotherapy and radiation treatment on body system among women suffering from cervical cancer Design: Descriptive study design. Setting: The current study was conducted at Menoufia oncology hospital. Sampling: A purposive sample included 50 women. Tools of data collection: Three tools were used. Tool (I) A structured interviewing questionnaire to assess women's general data, menstrual, obstetrics and family history, and clinical data about cervical cancer.   Tool (II) Assessment of women's knowledge about cervical cancer and its treatment. Tool (III) Assessment sheet for women complain from side effect of chemotherapy and radiation treatment. Results: About two-thirds of the studied women had adequate knowledge regarding cervical cancer chemotherapy and radiation while one-third of the studied women had inadequate knowledge regarding cervical cancer. The most symptoms that chemotherapy and radiation treatment affect on body system frequent infection, anorexia, tinnitus, difficult breath, irregular menstruation inflammation in the mouth , bone pain and diminished sexual arousal. Conclusion: Chemotherapy and radiation treatment had adverse effect on all body systems among women suffering from cervical cancer. Recommendations: Implementing health education for the women suffering from cervical cancer receiving chemotherapy and radiation treatment about the side effect s that may caused by treatment and the ways to alleviate it.