Background: The breast cancer diagnosis brings important changes to the way of living with physical and emotional changes due to discomfort, pain, deformity, dependence and loss of self-esteem. Aim of the study: This study aimed to evaluate the effect of psycho-educational nursing program on coping strategies among breast cancer patients. Research design: A quasi experimental design (one group pre and posttest) was utilized to achieve the aim of the study.  Setting: This study was conducted at the outpatient department of the clinical oncology center at the Nasser Institute Hospital. Sample: This study used a convenient sample of 50 adult women diagnosed with breast cancer. Tools for data collection: Data were collected by using tow tools: Socio demographic data and Adaptive Coping Strategies Questionnaire. Results: The result revealed significant improvement in coping strategies among breast cancer patients following psycho-educational program than pre. Conclusion: Psycho-educational program have useful effect in improving coping of patients with breast cancer. The study recommended that established educational seminar for health care providers, mental health nurses, and graduated nurses and under graduated students about utilization of psycho-educational intervention programs for those patients with breast cancer.