Background: Mastectomy women face many changes to their body in a more negative, ruminative way which may lead these women to criticize themselves and hence negatively affect not only their body-image, but also, their self-compassion. Aim of the study: This study aimed to evaluate the effect of acceptance and commitment training program on self-compassion and body-image among women with mastectomy. Resarch design: A quasi experimental design (one group pre and posttest) was utilized to achieve the aim of the study. Setting: The study was conducted at general surgery outpatient's clinics at Benha University Hospital which is affiliated to Ministry of High Education, Benha city, Qalubia Governorate. Subject: A purposive sample of (60) women with mastectomy was utilized in this study. Tools: Three tools were used for data collection: Tool (1): - A- structured interviewing questionnaire sheet included socio demographic as well as clinical characteristics of the studied women. Tool (2):- Self-Compassion Scale (SCS) & Tool (3):- Body-Image Scale. Results: The result of the present study revealed that, more than half of the studied women had high level of selfcompassion and more than half of the studied women had good level of body-image post-program implementation than before. Conclusion: Acceptance and commitment training program had a positive effect on self-compassion and body-image among the studied women with mastectomy. Recommendations: Generalization of acceptance and commitment training program for all women with mastectomy in all hospital to improve their self-compassion and hence their body-image.