Background: Sleeve gastrectomy is currently the only effective treatment for morbid obesity that results in substantial and sustainable weight loss, remission of obesity-related comorbidities, and improvement of quality of life. Aim: Assess the quality of life among patient with sleeve gastrectomy. Research design: A descriptive research design was used in carrying out this study. Setting: This study was conducted at Surgical Outpatient Clinic, in Benha University Hospital and Benha Teaching Hospital. Sample: A purposive sample of 150 patients with sleeve gastrectomy. Tool of data collection: Two tools were used for data collection as following: Tool (I): A structured interviewing questionnaire which of four parts: Socio-demographic data of the studied patient, medical history of patient's regarding sleeve gastrectomy, patients' knowledge regarding sleeve, and reported practices of patient's regarding sleeve gastrectomy. Tool (II): Quality of life among patients with sleeve gastrectomy. Results: 44% of the studied patients aged from 18 to less than 30 years old with mean was 42.61±9.35 years, 72.7% of them were female. 11.3% of them had poor total knowledge level regarding sleeve gastrectomy. 83.0% of the studied patients had satisfactory reported practices level regarding sleeve gastrectomy. 70.7% of studied patients had good total quality of life level. Conclusion: There was statistically positive correlation between studied patients total knowledge scores, total practices scores and their total quality of life scores regarding sleeve gastrostomy. Recommendation: Investigation of other factors that affect quality of sleeve gastrectomy patients.