Background: Virtual reality (VR) is an innovative technology and a computer-generated three-dimensional simulation that is associated with high empirical realism. It provides a vast range of sensory information to the user to interact with objects in a virtual environment and can be used to encourage nursing students develop skills in virtual hospital settings. Aim of the study was to evaluate the effect of virtual reality as a teaching strategy on pediatric nursing students' performance regarding cardiopulmonary resuscitation. Study design: An experimental design (study & control groups/ pre-posttest) was utilized. Setting: The pediatric nursing skills laboratory for third year/ Faculty of Nursing/ Benha University. Study subjects: A systematic random sample of (80) pediatric nursing students was selected from the pediatric nursing students who were studying the pediatric nursing course/third year/second semester during the academic year 2022/2023. Tools of data collection: Three tools were used; Tool I: A structured interviewing questionnaire, Tool II: Student's clinical evaluation checklist (pre/posttest) and Tool III: Virtual reality–teaching material usability questionnaire (posttest). Results: Vast majority of nursing students in study group had good knowledge level post-implementation compared with one third in control group. Also, majority of nursing students in the study group had competent total practices level regarding CPR postimplementation compared with more than half in the control group. Furthermore, vast majority of the nursing students in the study group had positive opinion about virtual reality-teaching material usability post-implementation. Conclusion: Virtual reality as a teaching strategy was effective in improving knowledge and enhancing practices of pediatric nursing students regarding CPR. Recommendations: Integrating virtual reality technology in nursing clinical courses to reinforce their performance in clinical settings.