Context: Crohn's and Ulcerative colitis disease are two common inflammatory bowel disease (IBD), which is a chronic inflammation in the gastrointestinal tract. Patients frequently experience painful symptoms and encounter adverse effects from medications due to the chronicity of the illness and its relapsing and remitting course, which can reduce quality of life (QoL). Aim: Evaluate the effect of educational program on quality of life and health promoting lifestyle behaviors for patients with inflammatory bowel diseases. Methods: The study used a quasiexperimental design, specifically employing a pre/post-test methodology on a convenience sample of (60) patient with IBD admitted within six months to gastrointestinal outpatient clinic and medicine department of Benha University Hospital. The study utilized the following tools: Patients' Structured Interview Questionnaire, Health Promoting Lifestyle Profile-II Scale, Short Inflammatory Bowel Disease (IBD) Questionnaire. Results indicated a statistically significant improvement in the overall mean score of patients' knowledge after implementing the educational program and at three months later (follow-up) (P<0.001). Besides, a statistically significant enhancement in the overall health-promoting lifestyle mean score, whereas preprogram the total mean score was 1.898±0.141 indicating unhealthy lifestyle which increase post implementation and at follow up to 2.429±0.131 and 2.721±0.146 respectively indicating healthy lifestyle. Total mean score of SIBDQ was 26.700±4.072 preprogram implementation which indicating poor QoL, but improved significantly to 51.083±8.749 and 56.633±8.144 post one month and at follow up respectively, which indicating better QoL (p<0.001).Conclusion: Patients with inflammatory bowel disease benefit from the implementation of educational programs that improve their quality of life and encourage healthy lifestyle choices. Recommendations: Implementing further study to investigate factors affecting compliance of IBDs patients with healthy lifestyle.