Background: Pneumonia in infants usually suffer from many complications and health problems as the course of treatment or a result of disease process. The aim of this study: Was to assess evidence-based practice regarding mothers' care for infants with pneumonia. Research design: A descriptive research design was be used in this study. Setting: The present study was conducted at Pediatrics Outpatient Clinic in Benha University Hospital. Sampling: A simple random sample was selected from all mothers accompanied with infants with pneumonia.  It includes 231 mothers. Tools: Two tools were used in this study.  I):  Structured interviewing questionnaire consist of three parts to assess socio-demographic characteristics of mothers, and personal characteristics of infants, medical history reported from mothers, and mothers' knowledge regarding pneumonia and evidence-based practice among infants with pneumonia. II): Mothers' EBP regarding caring of infants with pneumonia. Results: 63.2% of the studied mothers aged from 30- < 40 years old with Mean ±SD 33.52±5.24, while 55.8% of them had intermediate education, 76.2% of studied mothers had poor total knowledge level about pneumonia &EBP; 63.2 % of studied mothers had satisfactory total practices, while, 36.8 % of them had unsatisfactory total practices regarding care of the infant with pneumonia. Conclusion: There was highly statistically significant correlation between the studied mothers' total knowledge level and their total practices regarding pneumonia, p< 0.01. Recommendation: Health educational program for mothers should be developed and implemented to improve knowledge &enhancing practices about pneumonia and prevent complication.