Background: Substance abuse is one of the most important social deviations, which is foundation of many social damages and problems at the community level.  Every part of the substance abuser's life as social life, family life, work productivity, physical health and personal relationships is affected. Aim of the study: To evaluate the effect of psycho-educational program on quality of life and coping patterns of substance related disorders patients. Study design: A quasi-experimental design was utilized. Setting: The study was conducted at the outpatient clinics for addiction at the Psychiatric Mental Health Hospital in Benha City, Qalubia Governorate, which is affiliated to General Secretariat of Mental Health in Egypt. Study subjects: A convenience sample of 40 substance abusers was included. Tools of data collection: Three tools were used for data collection; Tool (1) Structured interview questionnaire sheet was used to collect data about socio demographic and clinical characteristics of the studied sample, Tool (2) Quality of life scale and Tool (3) Coping patterns questionnaire sheet. Results: There was a highly statistically significant improvement in total score of quality of life and total score of coping pattern between pre and post implementation of the program. Conclusion: The psycho-educational program had a positive effect on enhancement of quality of life and coping pattern among substance related disorder patients. Recommendations: Conducting psycho-educational program that educated substance abuser about causes, early detection, prevention and management of addiction and how to cope with their problems effectively.