Background: Health Belief Model is beneficial to assess the patients' beliefs regarding prevention of systemic lupus erythematosus complications to improve their beliefs and change their behaviors about the disease. Aim of study: To assess health belief model among patients regarding prevention of systemic lupus erythematosus complications. Research design: A descriptive design was utilized in this study. Setting: This study was conducted at Rheumatology Outpatient Clinics of Benha University Hospital and Benha Teaching Hospital. Sample: A purposive sample was used which included 83 patients with systemic lupus erythematosus. Tools of data collection: Two tools were used. 1): A structured interviewing questionnaires which included three parts: Part Ι: Socio-demographic data of patients with systemic lupus erythematosus. Part ІІ: Medical history of patients with systemic lupus erythematosus. Part ІІІ: Concerned with patients' knowledge about a) systemic lupus erythematosus disease and b) prevention of systemic lupus erythematosus disease. 2): Health belief model scale to assess patients belief regarding systemic lupus erythematosus disease. Results: 72.3%  of the studied patients were female, 94% of them had not enough monthly income, 89.2% of them had lupus flare due to sun exposure, 82% of them had medications' commitment about disease, 73.5% of them had complications from disease, 22.9% of them had poor total knowledge level regarding systemic lupus erythematosus, 43.4% of them had high total belief regarding prevention of systemic lupus erythematosus complications, there were a statistical significant relation between the total beliefs of patients with systemic lupus erythematosus and their place of residence about socio-demographic data P < 0.05. Conclusion: There was no statistical significant correlation between the total knowledge and the total beliefs of patients --with Systemic Lupus Erythematosus. Recommendation: Design and implement educational programs based on health belief model for systemic lupus erythematosus patients and regarding to prevention of complications.