Background: Organizational change and innovation are essential for health care organization's growth and development. Innovation can produce sudden and dramatic changes to the way of work. Aim of the study: To assess factors associated with nurses' readiness for organizational change and its relation to innovative work behaviors Study design: A descriptive correlational design was utilized. Setting: The study was conducted at Benha University Hospital in all inpatient medical and surgical units. Study subjects: simple random sample consisted of 322 nurses out of (1600). Tools of data collection: Two tools were used; Tool 1) Factor Readiness for Organizational Change Questionnaire and Tool 2) Innovative Work Behaviors Scale. Results: The most (90.0% & 91.6%) of nurses had high level of factors associated with nurses readiness for organizational change and high level innovative work behaviors respectively. The highest factors for organizational change were supervision readiness for change, followed by cognitive readiness for change, while the lowest factors were communicational readiness for change.  Conclusion: There was highly statistically significant positive correlation between total factors associated with nurses' readiness for organizational change and innovative work behaviors.  Recommendations: Directing efforts toward creating opportunities for nurses to learn and grow and enhance teamwork through collaboration between health team members as well as creation of autonomous work practice to improve organizational change.