Background: Organizational cynicism is one of the major issues that exists in healthcare organizations and associated with nurses' attitude. Also, it is undesirable attitude that is reported to have a negative impact on nurses' commitment and job embeddedness. Aim of the study: To assess effect of organizational cynicism management on nurses' organizational commitment and job embeddedness Study design: A Quasi-experimental design was utilized to meet the aim of this study. Setting: The study was conducted at general medical units at Benha University Hospital. Study subjects: A systematic simple random sample included 58 nurses chosen from the above mentioned units. Tools of data collection: Four different tools were used namely; Tool (I) Knowledge questionnaire about cynicism, Tool (II) Organizational cynicism attitude scale, Tool (III) Organizational commitment questionnaire and (IV) Job embeddedness scale. Results: Majority (94.8%) of nurses had inadequate knowledge regarding organizational cynicism at pre-program phase, but it improved to become (89.7% and 77.6%) adequate knowledge at immediate post and follow up program phase. Also, majority (86.2%) of nurses had high organizational cynicism attitude at pre-program phase, but it improved to (67.2% and 53.4%) at immediate post and follow up phases respectively. Conclusion: There was significant positive correlation between knowledge and nurses' organizational cynicism attitude and organizational commitment and job embeddedness during immediate post and follow up (after three months) of the program phases compared with pre-program phase. Recommendations: Developing an effective strategy to improve relations between nurses and their superiors, in order to decrease cynicism level.