Background: Computers are widely used in the office workplace, use of computers leads to some health hazards to human, which can be classified as physical, ergonomic, chemical, psychosocial and biological hazards. The aim of the study: Was to assess occupational health hazards among computer users in Benha University Administration. Research Design: A descriptive research design was used for this study. Setting: The study was conducted at Benha University Administration. Sample: Convenience sample of 100 computer users at Benha University Administration. Tools: Two tools were used in this study to collect the data. Tool 1: A structure interview questionnaire consists of three parts to assess socio demographic data of computer users, present and past medical history and computer users' knowledge regarding occupational health hazards. II: Observational checklist of computer users practices regarding preventing occupational health hazards. Results: 58% of the studied computer users took one training course. 18% of the studied computer users had hypertension as chronic disease, 30% of them had spinal surgery and 35% of them had Lasik eye surgery. 19% of them had good total knowledge level about occupational health hazards and 65% of the studied computer users had unsatisfactory total practices regarding prevention of occupational health hazards. Conclusion: There were highly statistically significant relations between the studied computer users' total practices scores and their total knowledge scores. Recommendation: Develop and implement educational programs to increase knowledge and practices of computer users regarding prevention of occupational health hazards.