Background: Workaholism among nurses may affect quality of nursing care by causing emotional exhaustion and stress. Also, nurses may face physical and psychological problems as result of workaholism. Aim of the study: To assess the relation between workaholism and the quality of nursing care among staff nurses. Study design: A descriptive correlational design was utilized. Setting: The study was conducted in all inpatient units at Sohag University Hospitals. Study subjects: A simple random sample 274 of staff nurses at Sohag University Hospitals. Tools of data collection: 1^st tool: Nurses' workaholism questionnaire, 2^nd tool: Quality of nursing care observational checklist. Results: Showed that more than two-thirds (70.1%) of staff nurses had a high level of workaholism and less than half (44.5%) of them reported a moderate level of quality of nursing care. Conclusion: The study concluded that, there was highly statistically significant positive correlation between total workaholism and quality of nursing care among staff nurses. Recommendations: Developing standard for nursing care procedures that help staff nurses providing high quality nursing care and examining the effect of workaholism on quality of work life among academic teaching staff.