Background: Nurses are in the frontline of the battle against COVID-19, nurses need to be capable of stress management to maintain their physical and psychological well-being in the face of a variety of stressors. A successful use of effective coping patterns during the COVID-19 pandemic helps nurses to manage stressful conditions. Aim of the study was to evaluate the effect of psycho educational program on psychological stress and coping patterns for Nurses Caring for Patients with COVID-19. Study Design: A quasi experimental design. Settings: Benha fever hospital which is located in Benha City, Qalubia Governorate. Study subjects: Convenient sample of all available number of nurses caring for patients with COVID-19 (n=60). Data collection tools: Tool I. Socio-demographic data questionnaires. Tool II. Emergency Psychological Stress Scale. Tool III. Coping Scale for Stressful Situations.  Results: More than two third of studied nurses had high stress pre-program intervention which decreased by the implementation of psycho educational program, also about half of them had poor coping skills pre-program intervention that decreased by the implementation of psycho educational program. Less than one third of them had good total level of coping pre-program that increased post program application. Conclusion: The psycho educational program had a positive effect on reducing psychological stress and improving coping patterns for Nurses Caring for Patients with COVID-19. Recommendations: Educational programs toward stress and coping patterns during COVID-19 should be implemented, not only for Nurses, but also for hospital staff as doctors, housekeeping, and admins in order to reduce stress and improve coping patterns during COVID-19.