Background: Covid-19 is a highly contagious disease. Pregnant women may be at high risk for covid-19 infection because of physiological changes and immunity suppression during pregnancy. Aim: To evaluate the effect of precautionary measures program on pregnant women's knowledge, attitudes and practices regarding novel covid-19. Design: A quasi-experimental design was conducted on purposive sample (120 pregnant women) to fulfill the aim of this study. Setting: Obstetrics and gynecological outpatient clinics affiliated at Benha university hospitals. Sample: Purposive sample that fulfill inclusion criteria. Tool: Four main tools were utilized: tool (I) interviewing questionnaire schedule, tool (II) knowledge questionnaire sheet to assess women's knowledge regarding novel covid-19, tool (III) modified likert scale to assess attitudes of pregnant women regarding novel covid-19 and tool (IV) women's reported practices questionnaire to assess women reported practices regarding precautionary measures for novel covid-19. Results: There was a highly statistical significant difference between the results of pre-intervention and post-intervention phase regarding all items of studied sample's knowledge, attitudes and practices about novel covid-19 with p≤0.001. Conclusion: Precautionary measures program had a positive effect on pregnant women's knowledge, attitudes and practices regarding novel covid-19.  Recommendation: Developing awareness program regarding global standard precaution for novel covid-19 to enhance knowledge, acquire positive attitudes and promote healthy practices for pregnant women.