Background: Heat-related illnesses are the most frequent health consequences of farmers' extended exposure to elevated temperatures.  Aim:  This study aimed to evaluate the effect of preventive program for heat stress-related illnesses resulting from climate change among farmers in alignment with sustainable development goals "Egypt Vision 2030". Design: A quasi- experimental design was utilized. Setting: The study was conducted at eight Agricultural Associations in Benha City. Sampling: Simple random sample was used to carry out the study. Total sample size included 160 farmers. Tools of data collection: One tool was used; An interviewing tool comprised of four parts as socio-demographic characteristics, medical history, farmers` knowledge about sustainable development goals, climate change and heat stress-related illnesses resulting from climate change and farmers` reported practices regarding prevention of the effects of heat stress resulting from climate change. Results: 6.9% of studied farmers had good knowledge regarding sustainable development goals, climate change and heat stress-related illnesses resulting from climate change pre preventive program that raised to 65.6% post preventive program, and 11.3% of studied farmers had satisfactory reported practices regarding prevention the effects of heat stress related illnesses resulting from climate change pre preventive program which enhanced to 76.9% post preventive program. Conclusion: Preventive program was efficient in improving farmers` knowledge and practices regarding heat stress-related illnesses resulting from climate change. Recommendations: Developing continuous preventive programs for farmers to raise the knowledge and practices about prevention of heat stress-related illnesses resulting from climate change.