Background: Parkinson's Disease is a progressive disease so patients require more assistance in everyday life which increase caregivers' burden. Aim: This study aimed to assess burden of care among caregivers of aging patient with Parkinson's disease. Research design: A descriptive research design was utilized in this study. Setting: This study was conducted at the Neurological outpatient clinic of Benha University Hospital and Benha Teaching Hospital. Sample: Simple random sample which included 218 aging patient with Parkinson's disease and their caregivers. Tools: Two tools were used in this study: Tool 1: Structured interviewing questionnaire to assess socio-demographic characteristics of the studied aging patient with Parkinson's disease and socio- demographic characteristics of caregivers, also their knowledge and their reported practice for the aging patient with Parkinson's disease. Tool 2: Burden level of caregivers regarding care of aging patient with Parkinson's disease. Results: 58.7% of studied aging patients were male and 43.1% of them aged from 60 to less than 70 years old, while; 61.9% of studied caregivers were female and age 42.7% of then aged from 40 to less than 50 years old. In addition, 63.8% of studied caregivers had poor total knowledge level, while had regular total reported practices regarding care of aging patient with PD. Moreover; 61.9% of them had high total burden level. Conclusion: There were highly statistically significant relation between total burden level and total practices among studied caregivers (P<0.001). Recommendations: Health educational program should be developed and implemented for patients with Parkinson disease and their caregivers to improve, updated knowledge and practices and reduce burden level.