Background: Hypovolemic shock is a severe life threatening emergency affecting all organ system. Nurses play a vital role in caring of patient with post traumatic hypovolemic shocked patient. Aim: Was to assess nurses' performance  (knowledge and practice) regarding care of patients with posttraumatic hypovolemic shock. Design: Descriptive research design was utilized. Setting: This study was conducted in Emergency and Intensive Care Unit, at Benha University Hospital. Sample: A convenience sample of 120 nurses from both sex were involved in the current study. Tools: Data was collected using two tools, I: Nurses knowledge questionnaire and II: Observational checklist for nurses practice. Results: 43.0% of the studied nurses were in age group 30-<40 years with the age 34.10 ± 7.69.  Also, 80.0% of them were females and 76.6% of them were married. The educational qualification in 43.3% of them had nursing school diploma and 30.0% of them had 1-<5 years of experience at emergency department and ICU, 56.7% of the studied nurses had satisfactory level of knowledge regarding care for post traumatic hypovolemic shocked patients. While, 43.3% of them had unsatisfactory level of knowledge.  73.3% of the studied nurses had competent level of practice regarding care for post traumatic hypovolemic shocked patients.  Conclusion: There was a significant statistical positive correlation between total level practice of the studied nurses and their total level of practice at P-value 0.042. Recommendations: Training program should be conducted about nursing management for hypovolemic shocked patient for nurses who are working at emergency department &Intensive care unit.