Background: Job crafting is a proactive behavior the changes that nurses make in the levels of job demands and job resources of constructive behavior in which workers aggregate resources to meet their needs which increases their job satisfaction. Aim: This study aimed to assess the relation between job crafting and job satisfaction among staff nurses. Research design: A descriptive, correlational design was used. Setting: The study was conducted at Benha University Hospital at Al-Kalubia Government. Subjects: A simple random sampling technique was used to select 169 staff nurses Tools of data collection: Data were collected by using two tools namely, the job crafting scale and the nurses' job satisfaction scale. Results: More than half of studied staff nurses had a low job crafting level and half of them had a high job satisfaction level. Conclusion: There was a positive correlation between job crafting and job satisfaction. Recommendations: Nurse managers stimulate nurses' job crafting process through the acceptance of job crafting as a positive and desirable practice. And providing a spiritual and trustful work environment for creating emotional relationships with nurses to enhance job satisfaction.