Cadmium (Cd) is a common environmental heavy metal contaminant, which has severe toxicity to human health. Traditional medicine plants frequently use Artemisia herba-alba (A. herba-alba) to treat a variety of illnesses. Three different groups, each of seven Wistar rats were set up. A normal control group: given saline solutions only. Rats in group two: received CdCl2 (5 mg/kgb.w. i.p). In group three: (CdCl2+ArtHA) treated orally by ArtHA ethanol extract (100 mg/kg/b.w.) and CdCl2 (5 mg/kg/b.w. i.p). Oxidative stress parameters and antioxidant enzymes were assessed in the liver, kidney, lung, and testis homogenates, as well as DNA damage. With a rise in malondialdehyde (MDA) levels in the Cd-treated group, the antioxidant enzyme activities were markedly downregulated. The amount of DNA damage was much higher in the Cd-treated group. Supplementing with A. herba-alb ethanol extract was extremely efficient and effectively restored the Cd-induced metabolic changes, making them close to the control values. The liver indicators (AST and ALT) as well as the renal damage markers (s. creatinine and s. urea) all showed significantly elevated levels.