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293484

Evaluation of In Vivo Anti-Diarrheal Activity of Selected Medicinal Plants Traditionally Prescribed for the Management of Diarrhea

Article

Last updated: 28 Dec 2024

Subjects

-

Tags

Medical chemistry

Abstract

This study explores the anti-diarrheal activities of aqueous-ethanolic extract of selected medicinal plants collected from Rawalakot Azad Kashmir, Pakistan. Different doses of the hydro-ethanolic extract of these Punica granatum, Aegle marmelos, Myrtus communis, and Helicteres isora as 250, 500, and 1000 mg/kg body weight (b.w.) were tested for antidiarrheal activity using castor oil-induced diarrhea in standardized animal specimens of albino rats (n = 5 in each group). Loperamide as a standard drug (control group, n= 5) and atropine (control group, n= 5) were utilized to evaluate the frequency of diarrheal feces and to check the intestinal transit by charcoal meal, respectively, while normal saline was used as a negative control group (n= 5). Anti-diarrheal activities of hydro-ethanolic extracts at different doses were compared to standard drug and negative control group. Results revealed that extracts of the selected plants at different doses induced significant (p < 0.05) reduction in number of diarrheal feces and this reduction was increased with increasing the dosage. This demonstrated that aqueous ethanolic extracts of the studied plants were able to increase the percentage inhibition of the charcoal meal movement and at high concentration (1000mg/kg b.w.), it significantly decreased the intestinal transit as compared with standard drug (atropine). From these results, it can be concluded that the selected traditional plants can have a significant antidiarrheal effect, but more research is recommended to explore the phytochemical constituents responsible for these anti-diarrheal activities.

DOI

10.21608/aujes.2023.182911.1112

Keywords

medicinal plants, Anti-diarrheal activities, ethanolic extracts, traditional treatments

Authors

First Name

Iftikhar

Last Name

Khan

MiddleName

Ahmad

Affiliation

Department of Eastern Medicine, University of Poonch, Rawalakot Azad Jammu and Kashmir-Pakistan

Email

iftikharahmad@upr.edu.pk

City

-

Orcid

-

First Name

Thomas

Last Name

Varkey

MiddleName

C

Affiliation

Banner University Medical Center

Email

thmsvrk7@gmail.com

City

Phoenix

Orcid

0000-0002-3586-2909

First Name

Muhammad

Last Name

Akram

MiddleName

-

Affiliation

Department of Eastern Medicine, Faculty of Medical Sciences, Government College University Faisalabad

Email

maram_0451@hotmail.com

City

-

Orcid

-

First Name

Naveed

Last Name

Munir

MiddleName

-

Affiliation

Department of Biochemistry, Government College University Faisalabad-Pakistan

Email

naveedmunir215@gmail.com

City

-

Orcid

-

First Name

Muhammad

Last Name

Riaz

MiddleName

-

Affiliation

Department of Allied Health Sciences, Sargodha Medical College, University of Sargodha-Pakistan

Email

riazmlt786@gmail.com

City

-

Orcid

-

First Name

Zachary

Last Name

Merhavy

MiddleName

Isaac

Affiliation

School of Medicine, Ross University, Bridgetown, Barbados

Email

zackmerhavy@gmail.com

City

Bridgetown

Orcid

0000-0002-8860-1980

Volume

4

Article Issue

2

Related Issue

40741

Issue Date

2023-04-01

Receive Date

2022-12-25

Publish Date

2023-04-01

Page Start

34

Page End

46

Print ISSN

2735-4229

Online ISSN

2735-4237

Link

https://aujes.journals.ekb.eg/article_293484.html

Detail API

https://aujes.journals.ekb.eg/service?article_code=293484

Order

4

Type

Original Research

Type Code

1,615

Publication Type

Journal

Publication Title

Aswan University Journal of Environmental Studies

Publication Link

https://aujes.journals.ekb.eg/

MainTitle

Evaluation of In Vivo Anti-Diarrheal Activity of Selected Medicinal Plants Traditionally Prescribed for the Management of Diarrhea

Details

Type

Article

Created At

28 Dec 2024