This study aims to define and debate the ecological crisis as presented in the fictional world of Margret Atwood. By reviewing what is meant by the term of “ecosystem" and many of its related derivatives such as ecocriticism, ecofeminism, and ecophilosophy, Atwood highlights how and why the ecology is deteriorating in her novel Oryx and Crake. It tackles and analyzes how science and capitalism have overwhelmed the universe and affect every single issue in human daily life. With reference to Margret Atwood's Oryx and Crake, the study is expected to analyze the ecological reality by using a literary interdisciplinary approach to ecocriticism for example but not limited, ecofeminism, wilderness, mimetic theory, psychological, sociological, cultural, gender, and mythological approaches through literary devices help understand and interpret the world in new ways such as symbolism, personification, dichotomy. It intends to highlight discussions on many concerns, such as animal abuse, corrupt society, genetic engineering, oppression of women, social inequality, and pollution in a world dominated by technocrats and controlled by capitalistic interests.