The current paper presents an energetic and exergetic of the Edfu sugarcane factory in Egypt. The major purpose of the present implementation is to separately analyze the major components of the cogeneration system for the sugar cane factory and to find and quantify the components with the highest energy losses and exergetic destruction. In the present study, exergy methods with traditional energy analysis are used to assess the thermodynamic efficiencies and losses. Based on the actual data of operating the factory, the results show that the system achieves an overall energy efficiency and an exergy efficiency of 75.17% and 36.85%, respectively. The maximum energy loss occurs in the juice heating process (JHP) at 66128.25 kW, followed by the boiler at 32499.4 kW. In addition, the maximum exergy destruction occurs in the power boiler at a rate of 130926.9 kW, so the boiler contributes 83% of the overall exergy destruction in the cogeneration system.